 หัวเรื่อง:ไม่มีชื่อไทย (ชื่ออังกฤษ : Pharmacokinetics and Withdrawal Times of Enrofloxacin in Ducks) ผู้เขียน: ดร.ณัฐสิทธิ์ ตันสกุล, รองศาสตราจารย์ , ดร.อำนาจ พัวพลเทพ, รองศาสตราจารย์ , นางสาวนฤมล กลางแก้ว ,  Napasorn Phaochoosak, Wanida Passudaruk สื่อสิ่งพิมพ์:pdf AbstractThe pharmacokinetic properties of enrofloxacin (EFX) were investigated in healthy ducks following a single administration of EFX with a dose of 10 mg/kg of body weight by intravenous (i.v.), intramuscular (i.m.), subcutaneous (s.c.) or oral (p.o.) route. The plasma concentration-time curve was analyzed using a two compartment model. Mean peak plasma concentration of EFX was 11.49 ? 1.17, 5.65 ? 0.36, 4.99 ? 0.87 and 4.87 ? 0.69 mg/ml after i.v., i.m., s.c. and p.o. administration, respectively. After a single i.v. administration, the pharmacokinetic parameters were found as follow; the elimination half-life (t1/2b) = 6.47 ? 2.85 h, the elimination rate constant (Kel ) = 0.70 ? 0.06 h-1,the apparent volume of distribution Vd(area) = 1.30 ? 0.22 L/kg and the total body clearance (ClB) = 0.89 ? 0.07 L/kg/h. Difference enrofloxacin bioavailability following i.m., s.c. and p.o. administration were 98.77 ? 0.05 %, 85.11 ? 2.71 % and 80.35 ? 0.29%, respectively. The results of pharmacokinetic properties of EFX in ducks should be provided with the dosage regimen, preslaughter withdrawal times and maximum residue limits for ducks. |